Dr. Caroline E. Paul is an associated partner, and co-supervisor of DCs number 5 and 9. Additionally, she is part of the career development workshop.
Caroline E. Paul received her Honours BSc and MSc degrees in Biological Chemistry at the University of Toronto with Prof. Mark Nitz, and her PhD degree at the University of Oviedo with Prof. Vicente Gotor-Fernández and Prof. Iván Lavandera within the EU project “Biotrains”. After postdoctoral work at TU Delft and Wageningen University, she was appointed as assistant professor in Biocatalysis at TU Delft in 2018 and associate professor in 2023. Her research highlights include the application of artificial cofactors in biocatalytic reactions, the discovery and characterization of redox enzymes, and the development of enzymatic cascades to obtain high-value products.
Caroline co-organized the NextGenChem@NL and BiocatNL symposiums for early career researchers in chemistry and biocatalysis in The Netherlands, and is the co-founder of NextGenBiocat, an annual international symposium for budding researchers in biocatalysis.
Key expertise
Hosting Institution
TU Delft is highly recognized, both nationally and internationally for its research portfolio and teaching capacities, as one of the top universities in the world. It is the largest university of engineering and sciences in the Netherlands, with ~27,000 students and an academic staff of >2,000, of which 300 are professors, publishing ~7,000 articles and books, and 250 patents, annually. It is a highly international environment, with 69% of PhD students and 57% of scientific staff having foreign nationality. TU Delft has outstanding teaching and research facilities, and has been awarded the “HR Excellence in Research” logo.
Contact
Delft University of Technology (TU Delft)
Biocatalysis section
Department of Biotechnology
Van der Maasweg 9
2629 HZ Delft
The Netherlands
https://nl.linkedin.com/in/carolineepaul
https://orcid.org/0000-0002-7889-9920
https://www.scopus.com/authid/detail.uri?authorId=25722196500
Relevant Publications
L. Martínez-Montero, D. Tischler, P. Süss, A. Schallmey, M.C.R. Franssen, F. Hollmann, C.E. Paul, Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade. Catal. Sci. Technol. 2021, 11, 5077. DOI:10.1039/D1CY00855B.
C.E. Paul, D. Eggerichs, A.H. Westphal, D. Tischler, W.J.H. van Berkel, Flavoprotein monooxygenases: Versatile biocatalysts. Biotechnol. Adv. 2021, 51, 107712. DOI: 10.1016/j.biotechadv.2021.107712.
C. Mügge, T. Heine, A.G. Baraibar, W.J.H. van Berkel, C.E. Paul, D. Tischler, Flavin-dependent N-hydroxylating enzymes: distribution and application. Appl. Microbiol. Biotechnol. 2020, 104, 6481. DOI: 10.1007/s00253-020-10705-w.
M. Ismail, L. Schroeder, M. Frese, T. Kottke, F. Hollmann, C.E. Paul, N. Sewald, Straightforward regeneration of reduced flavin adenine dinucleotide required for enzymatic tryptophan halogenation. ACS Catal. 2019, 9, 1389-1395. DOI: 10.1021/acscatal.8b04500.